Clobetasol Propionate 0.05% Clobetasol is a steroid, used in the treatment of allergic skin conditions.
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Synovate 0.05% Ointment contains Clobetasol Propionate, which belongs to the group of medicines called Topical corticosteroids. It is used to manage inflammatory skin conditions such as psoriasis, eczema, and dermatitis that have not responded to milder steroid creams or ointments.
Psoriasis
Psoriasis is a chronic skin condition characterized by red, flaky, crusty patches covered with silvery scales. The severity of psoriasis varies widely among individuals. For some, it is a minor irritation, while for others, it significantly affects their quality of life. Psoriasis involves cycles of mild or no symptoms followed by periods of more severe symptoms.
Eczema
Eczema refers to a group of conditions that cause the skin to become dry and irritated.
Lichen Planus
Lichen planus is a rash that can appear on various parts of the body, including the inside of the mouth. On the skin, it can be very itchy, though not always.
Lupus
Lupus is a long-term condition that causes joint pain, skin rashes, and fatigue. While there is no cure, early treatment can help improve symptoms.
Synovate 0.05% Ointment is not recommended for use in patients with other bacterial, fungal, or viral infections (such as herpes simplex, chicken pox, and tuberculosis). Before using Synovate 0.05% Ointment, inform your doctor if you have a skin infection, diabetes, adrenal gland problem, scheduled surgery, acne, plaques around your mouth, underarms, anus, or genitals, and liver diseases.
Synovate 0.05% Ointment may not interact with alcohol.
Synovate 0.05% Ointment should be used during pregnancy only if recommended by your doctor. Consult your doctor before using Synovate 0.05% Ointment.
Synovate 0.05% Ointment should be used with caution by breastfeeding women. Consult your doctor before using Synovate 0.05% Ointment.
Synovate 0.05% Ointment is not expected to have any effects on your ability to drive and use machines.
Synovate 0.05% Ointment should be used with caution in patients with kidney disease. Consult your doctor before using Synovate 0.05% Ointment
Synovate 0.05% Ointment should be used with caution in patients with liver disease. Consult your doctor before using Synovate 0.05% Ointment.
Autoimmune skin diseases such as psoriasis, eczema, lichen planus, and discoid lupus erythematosus
It works by blocking the production of certain chemical messengers that make the skin red, swollen and itchy.
Prolonged use or treatment of extensive areas can lead to systemic absorption and hypercorticism. Intensive treatment can cause skin atrophy, thinning, striae, and superficial blood vessel dilation, especially with occlusive dressings or skin folds. Rarely, it can provoke pustular psoriasis. Reports include pigmentation changes and hypertrichosis. If hypersensitivity appears, discontinue use immediately. Symptom exacerbation may occur.
Clobetasol Propionate is a highly potent topical corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictive properties. It inhibits late-phase allergic reactions through various mechanisms, such as reducing mast cell density, chemotaxis, and eosinophil activation, decreasing cytokine production, and inhibiting arachidonic acid metabolism.
For adults, the elderly, and children over 1 year, apply a thin layer to the affected areas twice daily, rubbing in gently and completely. For resistant lesions, especially with hyperkeratosis, occlusion with polythene film overnight may enhance the effect. Limit treatment to 2 consecutive weeks with a maximum of 50 gm per week. In children, limit courses to five days and review weekly.
Use creams for moist or weeping surfaces and ointments for dry, lichenified, or scaly lesions.
Co-administered drugs that inhibit CYP3A4 (e.g., ritonavir, itraconazole) can inhibit corticosteroid metabolism, increasing systemic exposure.
Limited data exists on Clobetasol Propionate use in pregnant women. Topical corticosteroids in pregnant animals can cause fetal development abnormalities. Use during pregnancy and lactation should only be if the benefits outweigh the risks. Unknown if excreted in human milk, caution is advised for nursing women.
Avoid long-term continuous therapy, especially in infants and children, due to the risk of adrenal suppression. Limit facial treatments and occlusion, as the face is prone to atrophic changes. Avoid eye contact to prevent glaucoma or cataract. Topical corticosteroids can be hazardous in psoriasis. Use antimicrobial therapy for infected inflammatory lesions. Withdraw corticosteroids if infection spreads and use systemic antimicrobials.
Store below 30°C, protected from light and moisture. Do not freeze. Keep out of reach of children.
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