Synovate 0.05% Ointment 10gm

Uses of Synovate 0.05% Ointment

Autoimmune skin diseases such as psoriasis, eczema, lichen planus, and discoid lupus erythematosus

How does Synovate 0.05% Ointment work?

It works by blocking the production of certain chemical messengers that make the skin red, swollen and itchy.

Side Effects of Synovate 0.05% Ointment

Prolonged use or treatment of extensive areas can lead to systemic absorption and hypercorticism. Intensive treatment can cause skin atrophy, thinning, striae, and superficial blood vessel dilation, especially with occlusive dressings or skin folds. Rarely, it can provoke pustular psoriasis. Reports include pigmentation changes and hypertrichosis. If hypersensitivity appears, discontinue use immediately. Symptom exacerbation may occur.

Quick Suggestions:

• Clobetasol is used to treat redness, swelling, itching, and discomfort of various skin conditions.
• It should be applied to the affected areas as a thin film, two times daily, or as advised by your doctor.
• Do not use it more often or for longer than advised by your doctor.
• Do not cover the area being treated with airtight dressings such as bandages unless directed by a doctor, as this may increase the risk of side effects.
• If you think the area of skin you are treating has become infected you should stop using Clobetasol and consult your doctor.
• Consult your doctor if your skin condition has not improved after four weeks of treatment. Do not use it for more than 4 consecutive weeks at a time.

Synovate is indicated for adults, the elderly, and children over 1 year for the following dermatoses:

• Psoriasis (excluding widespread plaque psoriasis)
• Recalcitrant dermatoses
• Lichen planus
• Discoid lupus erythematosus
• Other skin conditions unresponsive to less potent steroids

Pharmacology

Clobetasol Propionate is a highly potent topical corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictive properties. It inhibits late-phase allergic reactions through various mechanisms, such as reducing mast cell density, chemotaxis, and eosinophil activation, decreasing cytokine production, and inhibiting arachidonic acid metabolism.

Dosage & Administration of Synovate 0.05% Ointment

For adults, the elderly, and children over 1 year, apply a thin layer to the affected areas twice daily, rubbing in gently and completely. For resistant lesions, especially with hyperkeratosis, occlusion with polythene film overnight may enhance the effect. Limit treatment to 2 consecutive weeks with a maximum of 50 gm per week. In children, limit courses to five days and review weekly.

Use creams for moist or weeping surfaces and ointments for dry, lichenified, or scaly lesions.

Interaction

Co-administered drugs that inhibit CYP3A4 (e.g., ritonavir, itraconazole) can inhibit corticosteroid metabolism, increasing systemic exposure.

Contraindications

• Rosacea, acne vulgaris, and perioral dermatitis
• Primary cutaneous viral infections (e.g., herpes simplex, chickenpox)
• Hypersensitivity to the preparation
• Primary infected skin lesions caused by fungi (e.g., candidiasis, tinea) or bacteria (e.g., impetigo)
• Perianal and genital pruritus
• Dermatoses in children under 1 year, including dermatitis and napkin eruptions

Pregnancy & Lactation

Limited data exists on Clobetasol Propionate use in pregnant women. Topical corticosteroids in pregnant animals can cause fetal development abnormalities. Use during pregnancy and lactation should only be if the benefits outweigh the risks. Unknown if excreted in human milk, caution is advised for nursing women.

Precautions & Warnings

Avoid long-term continuous therapy, especially in infants and children, due to the risk of adrenal suppression. Limit facial treatments and occlusion, as the face is prone to atrophic changes. Avoid eye contact to prevent glaucoma or cataract. Topical corticosteroids can be hazardous in psoriasis. Use antimicrobial therapy for infected inflammatory lesions. Withdraw corticosteroids if infection spreads and use systemic antimicrobials.

Storage Conditions:

Store below 30°C, protected from light and moisture. Do not freeze. Keep out of reach of children.